Comprehensive suppression of all apoptosis-induced proliferation pathways as a proposed approach to colorectal cancer prevention and therapy.
Mutations in the WNT/beta-catenin pathway are present in the majority of all sporadic colorectal cancers ORG RED QUINOA (CRCs), and histone deacetylase inhibitors induce apoptosis in CRC cells with such mutations.This apoptosis is counteracted by (1) the signaling heterogeneity of CRC cell populations, and (2) the survival pathways induced by mitog